Neural cell adhesion molecule NCAM modulates dopamine-related behavior by regulating dopamine D2 receptor internalization in mice (Mus musculus Linnaeus, 1758) DISSERTATION Von

Neural cell adhesion molecule modulates dopaminergic signaling and behavior by regulating dopamine D2 receptor internalization.

The dopaminergic system plays an important role in the etiology of schizophrenia, and most antipsychotic drugs exert their functions by blocking dopamine D(2) receptors (D(2)Rs). Since the signaling strength mediated by D(2)Rs is regulated by internalization and degradation processes, it is crucial to identify molecules that modulate D(2)R localization at the cell surface. Here, we show that th...

The neural cell adhesion molecule associates with and signals through p21-activated kinase 1 to regulate neuronal growth cone morphology in mice (Mus musculus Linnaeus, 1758) Dissertation von

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The roles of neural cell adhesion molecules NCAM and CHL1 in the regulation of synaptic ultrastructure in mice (Mus musculus Linnaeus, 1758)

Murine neural stem cells engineered to express the neural adhesion molecule L1 under the control of the human GFAP promoter promote functional recovery after transplantation in a mouse spinal cord injury model in Mus musculus (Linneaus, 1758) DISSERTATION Von

Polysialic Acid Is Required for Dopamine D2 Receptor-Mediated Plasticity Involving Inhibitory Circuits of the Rat Medial Prefrontal Cortex

Decreased expression of dopamine D2 receptors (D2R), dysfunction of inhibitory neurotransmission and impairments in the structure and connectivity of neurons in the medial prefrontal cortex (mPFC) are involved in the pathogenesis of schizophrenia and major depression, but the relationship between these changes remains unclear. The polysialylated form of the neural cell adhesion molecule (PSA-NC...